Is the measurement of delivered dose a good performance measure? A characterization of delivered and respirable delivered dose in two brands of jet nebulizer
نویسندگان
چکیده
Background Use of a nebulizer facilitates rapid administration of high doses of drug, which is desirable for patients presenting with acute severe asthma. Breath-enhanced jet nebulizers direct the patient’s air flow through the nebulizer handset during inhalation producing aerosol output with a more favorable respirable profile. SideStream Plus (SS+; Philips Respironics) and Nebutech (NB; Salter Labs) are breathenhanced jet nebulizers, designed to produce a high delivered dose in a short treatment time. A previous in vitro characterization of delivered dose and droplet size distribution of arformoterol nebulized via the SS+ and the NB indicated that the SS+ performed favorably, compared with the NB. [1] We present results of an in vitro characterization of salbutamol sulphate (albuterol sulfate) delivery via the SS+ nebulizer and the NB nebulizer.
منابع مشابه
Variability in delivered dose and respirable delivered dose from nebulizers: are current regulatory testing guidelines sufficient to produce meaningful information?
BACKGROUND To improve convenience to patients, there have been advances in the operation of nebulizers, resulting in fast treatment times and less drug lost to the environment. However, limited attention has been paid to the effects of these developments on the delivered dose (DD) and respirable delivered dose (RDD). Published pharmacopoeia and ISO testing guidelines for adult-use testing utili...
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